Prof. Dr. Steven Dooley – Publikationen

SELECTED PUBLICATIONS SINCE 2004

1) Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis. Hammad S, Hoehme S, Friebel A, von Recklinghausen I, Othman A, Begher-Tibbe B, Reif R, Godoy P, Johann T, Vartak A, Golka K, Bucur PO, Vibert E, Marchan R, Christ B, Dooley S, Meyer C, Ilkavets I, Dahmen U, Dirsch O, Böttger J, Gebhardt R, Drasdo D, Hengstler JG. Arch Toxicol. 2014 May;88(5):1161-83. doi: 10.1007/s00204-014-1243-5. Epub 2014 Apr 19

2) Herrera B, Dooley S, Breitkopf-Heinlein K. Potential Roles of Bone Morphogenetic Protein (BMP)-9 in Human Liver Diseases. Int J Mol Sci. 2014 Mar 25;15(4):5199-220. doi: 10.3390/ijms15045199.

3) M.Y. Xu, X.F. Jia, Y. Qu, R.D. Zheng, Z.H. Yuan, H. Weng, S. Dooley, X.P. Wang, L.J. Zhang, L.G. Lu. Serum dihydroxyacetone kinase peptide m/z 520.3 as predictor of disease severity in patients with compensated chronic hepatitis B. J Transl Med. (2013), Sep 27;11:234.

4) S. Ghafoory, K. Breitkopf-Heinlein, Q. Li, C. Scholl, S. Dooley. S. Wölfl. Zonation of nitrogen and glucose metabolism gene expression upon acute liver damage in mouse. PLoS One. (2013), Oct 17;8(10).

5) C.R. van Roeyen, F.G. Scurt, S. Brandt, V.A. Kuhl, S. Martinkus, S. Djudjaj, U. Raffetseder, H.D. Royer, I. Stefanidis, S.E. Dunn, S. Dooley, H. Weng, T. Fischer, J.A. Lindquist, P.R. Meertens. Cold shock Y-box protein-1 proteolysis autoregulates its transcriptional activities. Cell Commun Signal. (2013), Aug 27;1163.

6) Y. Liu, H. Liu, C. Meyer, J. Li, S. Nadalin, A. Königsrainer, H. Weng, S. Dooley, P. ten Dijke. Transforming growth factor-β (TGF-β)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation. J Biol Chem. (2013), Oct 18;288(42):30708-19.

7) S. Ehnert, T. Lukoschek, A. Bachmann, J. Martinez-Sanchez, G. Damm, N.C. Nussler, S. Pscherer, U. Stöckle, S. Dooley, S. Mueller, A. K. Nussler. The right choice of antihypertensives protects primary human hepatocytes from ethanol and recombinant human TGF-β,-induced cellular damage. Hepatic Medicine: Evidence and Research (2013):5 31-41.

8) Y. Liu, H. Liu, C. Meyer, J. Li, S. Nadalin, A. Koenigsrainer, H. Weng, S. Dooley, P. ten Dijke. TGF-β mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 activation. J. Biol. Chem. (2013), September 4.

9) M. Vujic Spasic, R. Sparla, K. Mleczko-Sanecka, M.C. Migas, K. Breitkopf-Heinlein, S. Dooley, S. Vaulont, R.E. Fleming, M.U. Muckenthaler. Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload. Biochim Biophys Acta. (2013), Jan;1832(1):76-84.

10) H. Alborzinia, H. Schmidt-Glenewinkel, I. Ilkavets, K. Breitkopf-Heinlein, X. Cheng, P. Hortschansky, S. Dooley, S. Wölfl. Quantitative kinetics analysis of BMP2 uptake into cells and its modulation by BMP antagonists. J Cell Sci. (2013), Jan 1;126(Pt 1):117-27.

11) Y. Liu, C. Meyer, C. Xu, H. Weng, C. Hellerbrand, P. ten Dijke, S. Dooley. Animal Models of chronic liver diseases. Am J Physiol Gastrointest Liver Physiol. (2013), Mar 1;304(5):G449-68.

12) T. Yamaguchi, K. Matsuzaki, R. Inokuchi, R. Kawamura, K. Yoshida, M. Murata, J. Fujisawa, N. Fukushima, M. Sata, M. Kage, O. Nakashima, A. Tamori, N. Kawada, K. Tsuneyama, S. Dooley, T. Seki, K. Okazaki. Phosphorylated Smad2 and Smad3 signaling: Shifting between tumor suppression and fibro-carcinogenesis in chronic hepatitis C. Hepatol Res. (2013), Dec;43(12):1327-42.

13) S. Ehnert, T. Freude, C. Eicher, B. Burkhardt, J.J. Martinez Sánchez, J. Neumann, R. Mühl-Benninghaus, S. Dooley, S. Pscherer, A.K. Nussler. Darbepoetin inhibits proliferation of hepatic cancer cells in the presence of TGF-β. Arch Toxicol. (2014), Jan;88(1):89-96.

14) K. Hochrath, S. Ehnert, C.L. Ackert-Bicknell, Y. Lau, A. Schmid, M. Krawczyk, J.G. Hengstler, J. Dunn, K. Hiththetiya, B. Rathkolb, K. Micklich, W. Hans, H. Fuchs, V. Gailus-Durner, E. Wolf, M.H. de Angelis, S. Dooley, B. Paigen, B. Wildemann, F. Lammert, A.K. Nüssler. Modeling hepatic osteodystrophy in Abcb4 deficient mice. Bone. (2013), Áug;55(2):501-11.

15) J. Dzieran, J. Fabian, T. Feng, C. Coulouarn, I. Ilkavets, A. Kyselova, K. Breuhahn, S. Dooley, N.M. Meindl-Beinker. Comparative analysis of TGF-β/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines. PloS One. (2013), Aug 22;8(8):e72252.

16) L. Gobejishvili, S. Barve, K. Breitkopf-Heinlein, Y. Li, J. Zhang, D.V. Avila, S. Dooley, C.J. McClain. Rolipram attenuates bile duct ligation-induced liver injury in rats: a potential pathogenic role of PDE4. J Pharmacol Exp Ther. (2013), Oct;347(1):80-90.

17) C.L. Chen, H. Tsukomoto, J.C. Liu, C. Kashiwabara, D. Feldman, L. Sher, S. Dooley, S.W. French, L. Mishra, L. Petrovic, J.H. Jeong, K. Machida. Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells. J Clin Invest. (2013), Jul 1;123(7):2832-49.

18) R. Liebe, R.A. Hall, R.W. Williams, S. Dooley, F. Lammert. Systems genetics of hepatocellular damage in vivo and in vitro: identification of a critical network on chromosome 11 in mouse. Physiol Genomics. (2013), Oct 16;45(20):931-9.

19) P. Godoy, N.J. Hewitt, U. Albrecht, M.E. Andersen, N. Ansari, S. Bhattacharya, J.G. Bode, J. Bolleyn, C. Borner, J. Böttger, A. Braeuning, R.A. Budinsky, B. Burkhardt, N.R. Cameron, G. Camussi, C.S. Cho, Y.J. Choi, J.Craig Rowlands, U. Dahmen, G. Damm, O. Dirsch, M.T. Donato, J. Dong, S. Dooley, D. Drasdo, R. Eakins, K.S. Ferreira, V. Fonsato, J. Fraczek, R. Gebhardt, A. Gibson, M. Glanemann, C.E. Goldring., M.J. Gomez-Lechon, G.M. Groothuis,. L. Gustavsson, C. Guyot, D. Hallifax, S. Hammad, A. Hayward, D. Häussinger, C. Hellerbrand, P. Hewitt, S. Hoehme, H.G. Holzhütter, J.B. Houston, J. Hrach, K. Ito, H. Jaeschke, V. Keitel, J.M. Kelm, B. Kevin Park, C. Kordes, G.A. Kullak-Ublick, E.L. LeCluyse, P. Lu, J. Luebke-Wheeler, A. Lutz, D.J. Maltman, M. Matz-Soja, P. McMullen, I. Merfort, S. Messner, C. Meyer, J. Mwinyi, D.J. Naisbitt, A.K. Nussler, P.Olinga, F. Pampaloni, J. Pi, L. Pluta, S.A. Przyborski, A. Ramachandran, V. Rogiers, C. Rowe, C. Schelcher, K. Schmich, M. Schwarz, B. Singh, E.H. Stelzer, B. Stieger, R. Stöber, Y. Sugiyama, C. Tetta, W.E. Thasler, T. Vanhaecke, M. Vinken, T.S. Weiss, A. Widera, C.G. Woods, J.J. Xu, K.M Yarborough, J.G. Hengstler. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol. (2013), Aug;87(8):1315-530.

20) H. Weng, D.C. Feng, S. Radaeva, X.N. Kong, L. Wang, Y. Liu, Q. Li, H. Shen, Y.P. Gao, R. Müllenbach, S. Munker, T. Huang, J.L. Chen, V. Zimmer, F. Lammert, P.R. Mertens, W.M. Cai, S. Dooley, B. Gao. IFN-y inhibits liver progenitor cell proliferation in HBV-infected patients and in 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet-fed mice. J Hepatol. (2013), Oct;59(4):738-45.

21) C. Meyer, Y. Liu, S. Dooley. Caveolin and TGF-β entanglements. J Cell Physiol. (2013), Nov;228(11):2097-102.

22) C. Meyer, J. Dzieran, Y. Liu, F. Schindler, S. Munker, A. Müller, C. Coulouarn, S. Dooley. Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes. Cell Commun Signal (2013) Jan 22;11(1):6.

23) C. Meyer, Y. Liu, A. Kaul, I. Peipe, S. Dooley. Caveolin-1 abrogates TGF-β mediated hepatocyte apoptosis. Cell Death Dis. (2013), Jan 17;4:e466.

24) Q. Li, X. Gu, H. Weng, S. Ghafoory, Y. Liu, T. Feng, J. Dzieran, L. Li, I. Ilkavets, M. Kruithof-de Julio, S. Munker, A. Marx, A. Piiper, E.A. Alonso, N. Gretz, C. Gao, S. Wölfl, S. Dooley, K. Breitkopf-Heinlein. Bone morphogenetic protein-9 (BMP-9) induces epithelial to mesenchymal transition (EMT) in hepatocellular carcinoma cells. Cancer Sci. (2013), Mar;104(3):398-408.

25) N.M. Meindl-Beinker, K. Matsuzaki, S. Dooley. TGF-β Signaling in Onset and Progression of Hepatocellular Carcinoma. Dig Dis. (2012), 30(5):514-23.

26) H. Alborzinia, H. Schmidt-Glenewinkel, I. Ilkavets, K. Breitkopf-Heinlein, X. Cheng, P. Hortschansky, S. Dooley, S. Wölfl. Quantitative kinetic analysis of BMP2 uptake into cells and its modulation by BMP-antagonists. J Cell Sci. (2012), Oct 17. (Epub ahead of Print)

27) M.V. Spasic, R. Sparla, K. Mleczko-Sanecka, M.C. Migas, K. Breitkopf-Heinlein, S. Dooley, S. Vaulont, R.E. Fleming, M.U. Muckenthaler. Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload. Biochim Biophys Acta (2012) Aug Jan;1832(1):76-84.

28) A. Teufel, D. Becker, S.N. Weber, S. Dooley, K. Breitkopf-Heinlein, T. Maass, K. Hochrath, M. Krupp, J. U. Marquardt, M. Kolb, B. Korn, C. Niehrs, T. Zimmermann, P.R. Galle, F. Lammert. Identification of RARRES1 as a core regulator in liver fibrosis. J Mol Med ( 2012), Jun 6. (Epub ahead of print)

29) S. Ehnert, J. Zhao, S. Pscherer, T. Freude, S. Dooley, A. Kolk, U. Stockle, A.K. Nuessler, R. Hube. Transforming growth factor beta1 inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy? BMC Med. (2012), Sep 7;10(1):101. (Epub ahead of print)

30) S. Karkampouna, P. Ten Dijke, S. Dooley, M.K. Julio. TGF-β Signaling in Liver Regeneration. Curr Pharm Des. (2012), 18(27):4103-13.

31) Y. Wu, Q. Li, X. Zhou, J. Yu, Y. Mu, S. Munker, C. Xu, Z. Shen, R. Müllenbach, Y. Liu, L. Li, N. Gretz, D. Zieker, J. Li, K. Matsuzaki, Y. Li, S. Dooley, H. Weng. Decreased levels of active SMAD2 correlate with poor prognosis in gastric cancer. Plos One (2012), 7(4):e35684.

32) D. Feng, X. Kong, H. Weng, O. Park, H. Wang, S. Dooley, M.E. Gershwin, B. Gao. Interleukin-22 promotes proliferation of liver stem/progenitor cells in mice and patients with chronic HBV infection. Gastroenterology (2012), Jul;143(1):188-98.e7.

33) S. Ghafoory, K. Breitkopf-Heinlein, Q. Li, J. Dzieran, C. Scholl, S. Dooley, S. Wölfl. A fast and efficient polymerase chain reaction-based method for the preparation of in situ hybridization probes. Histopathology (2012), Aug;61(2):306-13

34) K. Wegner*, A. Bachmann*, J.U. Schad, P. Lucarelli, S. Sahle, P. Nickel, C. Meyer, U. Klingmüller, S. Dooley, U. Kummer. Dynamics and feedback loops in the transforming growth factor β signaling pathway. Biophys Chem. (2012), 162:22-24.

35) N. Kawelke, M. Vasel, C. Sens, Av Au, S. Dooley, I.A. Nakchbandi. Fibronectin protects from excessive liver fibrosis by modulating the availability of and responsiveness of stellate cells to active TGF- β. PLoS One. (2011), 6(11):e28181.

36) O. Pivovarova, E. Fisher, K. Dudziak, I. Ilkavets, S. Dooley, P. Slominsky, S. Limborska, M.O. Weickert, J. Spranger, A. Fritsche, H. Boeing, A.F. Pfeiffer, N. Rudovich. A Polymorphism within the connective tissue growth factor (CTGF) gene has no effect on non-invasive markers of beta-cell area and risk of type 2 diabetes. Dis Markers. (2011), 31(4):241-6.

37) S. Dooley, P. ten Dijke. TGF-β in progression of liver disease. Cell Tissue Res. (2012), 347(1):245-56.

38) Y. Liu, C. Meyer, A. Müller, F. Herweck, Q. Li, R. Müllenbach, P.R. Mertens, S. Dooley, H. Weng. IL-13 induces connective tissue growth factor in rat hepatic stellate cells via TGF- β independent Smad signaling. J Immunol. (2011), 187(5), 2814-23.

39) H. Köppel, E. Riedl, M. Braunagel, S. Sauerhoefer, S. Ehnert, P. Godoy, P. Sternik, S. Dooley, B.A. Yard. L-carnosine inhibits high-glucose-mediated matrix accumulation in human mesangial cells by interfering with TGF- β production and signaling. Nephrol Dial Transplant. (2011), 26(12), 3852-8.

40) J. Lin, L. Schyschka, R. Mühl-Benninghaus, J. Neumann, L. Hao, N. Nüssler, S. Dooley, L. Liu, U. Stöckle, A.K. Nüssler, S. Ehnert. Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism. Arch Toxicol. (2012), 86(1), 87-95.

41) H. Weng, H. Li, S. Dooley. Inflammation does not always kill hepatocytes during liver damage. Hepatology (2011), 54(1), 366.

42) O. Park, H. Wang, H. Weng, L. Feigenbaum, H. Li, S. Yin, S.H. Ki, S.H. Yoo, S. Dooley, F.S. Wang, H.A. Young, B. Gao. In vivo consequences of liver-specific interleukin-22 expression: Implications for human liver disease progression. Hepatology. (2011), 54(1), 252-61.

43) Y.J. Wu, W.M. Cai, Q. Li, Y. Liu, H. Shen, P.R. Mertens, S. Dooley. H. Weng. Long-term antifibrotic action of interferon-gamma treatment in patients with chronic hepatitis B virus infection. Hepatobiliary Pancreat Dis Int. (2011), 10(2), 151-7.

44) I. Bergheim, P.K. Eagon, S. Dooley, K. Breitkopf-Heinlein. Alcoholic liver disease and exacerbation by malnutrition and infections: what animal models are currently available? Ann N Y Acad Sci (2011), 1216, 41-9.

45) C. Meyer, P. Godoy, A. Bachmann, Y. Liu, D. Barzan, I. Ilkavets, P. Maier, C. Herskind, J. Hengstler and S. Dooley. Distinct role of endocytosis for Smad and non Smad TGF-β signaling regulation in hepatocytes. J Hepatol (2011), 55(2), 369-78.

46) S. Ehnert, J. Baur, A. Schmitt, M. Neumaier, M. Lucke, S. Dooley, H. Vester, B. Wildemann, U. Stöckle, Nussler AK. TGF-β1 as possible link between loss of bone mineral density and chronic inflammation. PLoS One (2010), 5(11), e14073.

47) D. Schuhmann, P. Godoy, C. Weiß, A. Gerloff, M.V. Singer, S. Dooley, U. Böcker.
Interfering with interferon-Y signalling in intestinal epithelial cells: selective inhibition of apoptosis: maintained secretion of anti-inflammatory interleukin-18 binding protein. Clin Exp Immunol. (2011), 163(1), 65-76.

48) S. Zellmer, W. Schmidt-Heck, P. Godoy, H. Weng, C. Meyer, T. Lehmann, T. Sparna, W. Schormann, S. Hammad, C. Kreutz, J. Timmer, F. von Weizsäcker, P.A. Thürmann, I. Merfort, R. Guthke, S. Dooley, J. Hengstler, R. Gebhardt. The transcription factors ETF, E2F and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes, Hepatology (2010), 52(6), 2127-36.

49) B. Denecke, L. Wickert, Y. Liu, L. Ciuclan, S. Dooley and N.M. Meindl-Beinker. Smad7 dependent gene expression profiling highlights crosstalk of TGF-β and BMP2 pathways and the importance of sugar metabolism in HSC transdifferentiation. World J Gastroenterology (2010), 16(41), 5211-5224.

50) K. Mleczko-Sanecka, G. Casanovas, A. Ragab, K. Breitkopf, A. Mueller, M. Boutros, S.Dooley, M.W. Hentze, and M.U. Muckenthaler. SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. BLOOD (2010), 115(13), 2657-65.

51) L. Ciuclan, S. Ehnert, I. Ilkavets, H.L. Weng, H. Gaitantzi, H. Tsukamoto, E. Ueberham, N.M. Meindl-Beinker, M. Singer, K. Breitkopf and S. Dooley. TGF-ß enhances alcohol dependent hepatocyte damage via downregulation of alcohol dehydrogenase I. J Hepatol (2010), 52(3), 407-416.

52) S. Ehnert, M. Knobeloch, A. Blankenstein, A. Müller, U. Böcker, S. Gillen, H. Friess, W. Thasler, S. Dooley, A. Nussler. NeoHepatocytes from alcoholics and controls express hepatocyte markers and display reduced fibrogenic TGF-b/Smad3 signaling: advantage for cell transplantation? Alcohol Clin Exp Res (2010), 34(4), 708-18.

53) T. Rauen, U. Raffetseder, B.C. Frye, S. Djudjaj, P.F. Muehlenberg, F. Eitner, U. Lehndahl, J. Bernhagen, S. Dooley and P.R. Mertens. YB-1 acts as ligand for Notch-3 receptors and modulates receptor activation. J Biol Chem (2009), 284(39), 26928-26940.

54) S.L. Haas, B. Fitzner, R. Jaster, E. Wiercinska, H. Gaitantzi, R. Jesenowski, J.M. Löhr, M.V. Singer, S. Dooley and K. Breitkopf. Transforming growth factor (TGF)-β induces nerve growth factor (NGF) expression in pancreatic stellate cells by activation of the ALK-5 pathway. Growth Factors (2009), 27(5), 289-299.

55) B.C. Frye, S. Halfter, S. Djudjaj, P. Muehlenberg, S. Weber, U. Raffetseder, A. En-Nia, H. Knott, J.M. Baron, S. Dooley, J. Bernhagen, P.R. Mertens. Y-box protein-1 is actively secreted through a non-classical pathway and acts as an extracellular mitogen. EMBO Rep (2009), 10(7), 783-789.

56) S. Ehnert, A. Lehmann, U. Böcker, S. Dooley and A.K. Nüssler. NeoHepatocytes generated from patients with chronic liver disease can be used for autologous cell transplantation. Chirurgisches Forum (2009), Band 38.

57) H.L. Weng, Y. Liu, J.L. Chen, T. Huang, P. Godoy, J.H. Hu, C. Zhou, F. Stickel, A. Marx, R. M. Bohle, V. Zimmer, F. Lammert, S. Müller, P.R. Mertens, M.V. Singer, H.K. Seitz and S. Dooley. The etiology of liver damage imparts TGF-ß 1 or IL-13 as driving force of fibrogenesis. Hepatology (2009), 50(1), 230 – 243.

58) P. Godoy, J.G. Hengstler, I. Ilkavets, C. Mayer, A. Bachmann, A. Müller, G. Tuschl, S. Müller and S. Dooley. Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid de-differentiation and TGF-ß-induced apoptosis. Hepatology (2009), 49(6), 2031-43.

59) S. Ehnert, A.K. Nussler, A. Lehmann and S. Dooley. Blood monocyte derived Neo-Hepatocytes as in vitro test system for drug-metabolism. Drug Metab Dispos (2008), 36, 1922-1929.

60) S. Dooley, J. Hamzavi, L. Ciuclan, P. Godoy, I. Ilkavets, S. Ehnert, E. Ueberham, R. Gebhardt, S. Kanzler, A. Geier, K. Breitkopf, H. Weng and P. R. Mertens. Hepatocyte specific Smad7 expression attenuates TGF-β mediated fibrogenesis and protects against liver damage. Gastroenterology (2008), 135, 642–659.

61) J. Hamzavi, S. Ehnert, P. Godoy, L. Ciuclan, H. Weng, P.R. Mertens, P. Heuchel and S. Dooley. Disruption of the Smad7 gene enhances CCl4-dependent liver damage and fibrogenesis in mice. J Cell Mol Med (2008), 12, 2130-2144.

62) N.M. Meindl-Beinker and S. Dooley. Transforming growth factor-β and hepatocyte transdifferentiation in liver fibrogenesis. Journal of Gastroenterology and Hepatology (2008) Suppl. 1; S122-S127.

63) H.L. Weng , L. Ciuclan, Y. Liu, J. Hamzavi, P. Godoy, H. Gaitantzi, S. Kanzler, R. Heuchel, U. Ueberham, R. Gebhardt, K. Breitkopf and S. Dooley. Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes. Hepatology (2007), 46, 1257-1270.

64) X.-S. Ju, D. Ruau, C. Becker, E. Wiercinska, C. Bartz, B. Erdmann, S. Dooley and M. Zenke. Transforming growth factor β1 (TGF-β1) upregulates interferon regulatory factor 8 (IRF-8) during Langerhans cell development. Eur J Immunol (2007), 37, 1174-1183.

65) P.L. Jansen, M. Kever, R. Rosch, E. Krott, M. Jansen, A. Alfonso-Jaume, S. Dooley, U. Klinge, D.H. Lovett and P.R. Mertens. Polymeric meshes induce zonal regulation of matrix metalloproteinase-2 gene expression by macrophages and fibroblasts. FASEB J (2007), 21, 1047-1057.

66) O. Purps, B. Lahme, A.M. Gressner, N.M. Meindl-Beinker and S. Dooley. Loss of TGF-ß dependent growth control during HSC transdifferentiation. Biochem Biophys Res Commun (2007), 353, 841-847.

67) H. Weng, P.R. Mertens, A.M. Gressner and S. Dooley. IFN-ß abrogates profibrogenic TGF-ß signaling in the liver by targeting expression of inhibitory and receptor Smads. J Hepatol (2007), 46, 295-303.

68) H. Seyhan, J. Hamzavi, E. Wiercinska, A.M. Gressner, P.R. Mertens, J. Kopp, R.E. Horch, K. Breitkopf and S. Dooley. Liver fibrogenesis due to cholestasis is associated with increased Smad7 expression and Smad3 signaling. J Cell Mol Med (2006), 10, 922-932.

69) U. Klingmüller, A. Bauer, S. Bohl, P. J. Nickel, K. Breitkopf, S. Dooley, S. Zellmer, C. Kern, I. Merfort, T. Sparna, J. Donauer, G. Walz, M. Geyer, C. Kreutz, M. Hermes, F. Götschel, A. Hecht, D. Walter, L. Egger, K. Neubert, C. Borner, M. Brulport, W. Schormann, C. Sauer, F. Baumann, R. Preiss, S. MacNelly, P. Godoy, E. Wiercinska, L. Ciuclan, J. Edelmann, K. Zeilinger, M. Heinrich, U. M. Zanger, R. Gebhardt, T. Maiwald, R. Heinrich, J. Timmer, F. v. Weizsäcker and J. G. Hengstler. Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. Syst Biol (Stevenage) (2006), 153, 433-447.

70) J. Kopp, H. Seyhan, B. Müller, J. Lanczak, E. Pausch, A.M. Gressner, S. Dooley and R.E. Horch. N-acetyl-L-cysteine abrogates fibrogenic properties of fibroblasts isolated from Dupuytren´s disease by blunting TGF-ß signaling. J Cell Mol Med (2006), 10, 157-165.

71) E. Wiercinska, L. Wickert, B. Denecke, H.M Said, J. Hamzavi, A. M. Gressner, M. Thorikay, P. ten Dijke, P. R. Mertens, K. Breitkopf and S. Dooley. Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells. Hepatology (2006), 43, 1032-1041.

72) S. Dooley, H. M.Said, A. M. Gressner, J. Floege, A. A. En Nia, and P.R. Mertens. YB-1 is the crucial mediator of antifibrotic IFN-Y effects. J Biol Chem (2006), 281, 1784-1795.

73) I. Poser, T. Rothhammer, S. Dooley, R. Weiskirchen and A.K. Bosserhoff. Characterization of Sno expression in malignant melanoma. Int J Oncol (2005), 26, 1411-1417.

74) H.L. Weng, B.E. Wang, J.D. Jia, W.F. Wu, J.Z. Xian, P.R Mertens, W.M. Cai and S. Dooley. Effect of interferon-gamma on hepatic fibrosis in chronic hepatitis B virus infection: a randomized controlled study. Clinical Gastroenterology and Hepatology (2005), 3, 819-828.

75) J. Kopp, E. Preis, H. Said, B. Hafemann, L. Wickert, A.M. Gressner, N. Pallua and S. Dooley. Abrogation of TGF-ß signaling by SMAD7 inhibits collagen gel contraction of human dermal fibroblasts. J Biol Chem (2005), 280, 21570-6.

76) S. Lindert, L. Wickert, I. Sawitza, A.M. Gressner, S. Dooley and K. Breitkopf. Transdifferentiation-dependent expression of alpha-SMA in hepatic stellate cells does not involve TGF-ß pathways leading to coinduction of collagen type I and thrombospondin-2. Matrix Biol (2005), 24, 198-207.

77) K. Breitkopf, I. Sawitza, J. H. Westhoff, L. Wickert, S. Dooley and A. M. Gressner. Thrombospondin-1 acts as a strong promoter of TGF-ß effects via two distinct mechanisms in hepatic stellate cells. GUT (2005), 54, 673-681.

78) U. Bolkenius, D. Hahn, A.M. Gressner, K. Breitkopf, S. Dooley and L. Wickert. Glucocorticoids decrease the bioavailability of TGF-β which leads to a reduced TGF-β signaling in hepatic stellate cells. Biochem Biophys Res Commun (2004), 325, 1264–1270.

79) J. Kopp, G.Y. Wang, P. Kulmburg, S. Schultze-Mosgau, J.N. Huan, K. Ying, H. Seyhan, M.D. Jeschke, U. Kneser, A.D. Bach, S.D. Ge, S. Dooley and R.E. Horch. Accelerated wound healing by in vivo application of keratinocytes overexpressing KGF. Mol Ther (2004), 10, 86-96.

80) S. Dooley, J. Hamzavi, K. Breitkopf, E. Wiercinska, H. M. Said, J. Lorenzen, P. ten Dijke and A. M. Gressner. Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology (2003), 125, 178-191.

81) J. Kanta, S. Dooley, B. Delvoux, S. Breuer, T. D’Amico and A. M. Gressner. Tropoelastin expression is upregulated during activation of hepatic stellate cells and in the livers of CCl4-cirrhotic rats. Liver (2002), 22, 220-227.

82) F. Berg, B. Delvoux, C. Gao, J. H. Westhoff, K. Breitkopf, A. M. Gressner and S. Dooley. Divergence of TGF-ß signaling in activated hepatic stellate cells downstream from Smad2 phosphorylation. Signal Transduction (2002), 1-3, 11-18.

83) T. Ostendorf, U. Kunter, C. van Roeyen, S. Dooley, N. Janjic, J. Ruckman, F. Eitner and J. Floege. The effects of PDGF antagonism in experimental glomerulonephritis are independent of the TGF-ß system. J Am Soc Nephrol (2002), 13, 658-667.

84) S. Dooley, M. Streckert, B. Delvoux and A.M. Gressner. Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblasts. Biochem Biophys Res Commun (2001), 283, 554-562.

85) S. Dooley, B. Delvoux, M. Streckert, L. Bonzel, M. Stopa, P. ten Dijke and A.M. Gressner. TGF-ß signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGF-ß signal transduction during transdifferentiation of hepatic stellate cells FEBS Letters (2001), 502, 4-10.

86) M. Stopa, D. Anhuf, L. Terstegen, P. Gatsios, A. M. Gressner and S. Dooley. Participation of Smad2, Smad3 and Smad4 in TGF-ß-induced activation of Smad7. The TGF-ß response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation. J Biol Chem (2000), 275, 29308-29317.

87) S. Dooley, B. Delvoux, B. Lahme, K. Mangasser-Stephan and A. M. Gressner. Modulation of TGF-ß response and signaling during transdifferention of rat hepatic stellate cells to myofibroblasts. Hepatology (2000), 31, 1094-1106.

88) M. Stopa, V. Benes, W. Ansorge, A.M. Gressner and S. Dooley. Genomic locus and promoter region of rat SMAD7, an important antagonist of TGF-ß signaling. Mammal Genome (2000) 11, 169-176.

89) C. Pfohler, T. Fixemer, V. Jung, S. Dooley, K. Remberger and H. Bonkhoff. In situ hybridization analysis of genes coding collagen IV alpha1 chain, laminin beta1 chain, and S-laminin in prostate tissue and prostate cancer: increased basement membrane gene expression in high-grade and metastatic lesions. Prostate (1998), 36, 143-150.

90) K. Mangasser-Stephan, S. Dooley, C. Welter, W. Mutschler and R.G. Hanselmann. Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display. Biochem Biophys Res Commun (1997), 234, 153-156.

91) H. Huwer, G. Kalweit, M. Engel, C. Welter, S. Dooley and E. Gams. Expression of the candidate tumor suppressor gene nm23 in the bronchial system of patients with squamous cell lung cancer. Eur J Cardiothorac Surg (1997), 2, 206-209.

92) T. Seib, N. Blin, K. Hilgert, M. Seifert, B. Theisinger, M. Engel, S. Dooley, K.D. Zang and C. Welter. The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55kb on chromosome 21q22.3. Genomics (1997), 40, 200-202.

93) S. Dooley, I. Herlitzka, R. Hanselmann, A. Ermis, W. Henn, K. Remberger, T. Hopf and C. Welter. Constitutive expression of c-fos and c-jun, overexpression of ets-2 and reduced expression of metastasis suppressor gene nm23-H1 in rheumatoid arthritis. Ann Rheum Dis (1996), 55, 298-304.

94) S. Dooley, T. Seib, C. Welter and N. Blin. c-myb intron I protein binding and association with transcriptional activity in leukemic cells. Leukemia Res (1996), 20, 429-439.

95) S.J. Scherer, C. Welter, K.D. Zang and S. Dooley. Specific in vitro binding of p53 to the promoter region of the human mismatch repair gene hMSH2. Biochem Biophys Res Comm (1996), 221, 722-728.

96) B. Theisinger, G. Seitz, S. Dooley and C. Welter. A second trefoil protein, ITF/hP1.B, is transcribed in human breast cancer. Breast Cancer Res Treat (1996), 38, 145-151.

97) S.J. Scherer, T. Seib, G. Seitz, S. Dooley and C. Welter. Isolation and characterization of the human mismatch repair gene hMSH2 promoter region. Hum Genet (1996), 97, 114-116.

98) T. Seib, S. Dooley and C. Welter. Characterization of the genomic structure and the promoter region of the human intestinal trefoil factor. Biochem Biophys Res Comm (1995), 214, 195-199.

99) M. Engel, M. Véron, B. Theisinger, M.L. Lacombe, T. Seib, S. Dooley and C. Welter. A novel serine/threonine specific protein phosphotransferase activity of Nm23/nucleoside diphosphate kinase. Eur J Biochem (1995), 234, 200-207.

100) S. Dooley, I. Wundrack, N. Blin and C. Welter. Coexpression pattern of c-myc associated genes in a small cell lung cancer cell line with high steady state c-myc transcription. Biochem Biophys Res Comm (1995), 213, 789-795.

101) M. Seifert, T. Seib, M. Engel, S. Dooley and C. Welter. Isolation and characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396. Biochem Biophys Res Comm (1995), 215, 910-914.

102) H. Huwer, M. Engel, C. Welter, S. Dooley, G. Kalweit, P. Feindt and E. Gams. Squamous cell carcinoma of the lung: Does the nm23 gene expression correlate to the tumor stage? Thorac Cardiovasc Surgeon (1994), 42, 298-301.

103) M. Engel, O.G. Issinger, I. Lascu, T. Seib, S. Dooley, K.D. Zang and C. Welter. Phosphorylation of nm23/nucleoside diphosphate kinase by casein kinase 2 in vitro. Biochem Biophys Res Commun (1994), 199, 1041-1048.

104) S. Dooley, I. Wundrack, C. Welter and N. Blin. Constitutive c-myc overexpression and P1/P2 promoter shift in a small cell lung cancer cell line. Int J Oncol (1994), 5, 65-68.

105) S. Merscher, R. Hanselmann, C. Welter and S. Dooley. Nuclear runoff transcription analysis using chemiluminescent detection. Biotechniques (1994), 16, 1024-1026.

106) T. Seib, C. Welter, M. Engel, B. Theisinger and S. Dooley. presence of regulatory sequences within intron 4 of human and murine c-myb genes. Biochem Biophys Acta (1994), 1219, 285-292.

107) S. Dooley, T. Seib, M. Engel, B. Theisinger, H. Janz, K. Piontek, K.D. Zang and C. Welter. Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1. Hum Genet (1994), 93, 63-66.

108) M. Engel, B. Theisinger, T. Seib, G. Seitz, H. Huwer, K.D. Zang, C. Welter and S. Dooley. High levels of nm23-H1 and nm23-H2 messenger RNA in human squamous-cell lung carcinoma are associated with poor differentiation and advanced tumor stages. Int J Cancer (1993), 55, 375-379.

109) S. Dooley, T. Seib, M. Engel and C. Welter. A rapid method to determine the orientation of blunt end ligated polymerase chain reaction products. Electrophoresis (1993), 14, 662-663.

110) A. Ermis, T. Hopf, R. Hanselmann, K. Remberger, C. Welter, S. Dooley, K.D. Zang and W. Henn. Clonal chromosome aberrations in cell cultures of synovial tissue from patients with rheumatoid arthritis. Genes Chromosomes Cancer (1993), 6, 232-234.

111) I. Wundrack, A. Ruffing, C. Welter, N. Blin, N. and S. Dooley. Regulation of constitutive c-myc overexpression in small cell lung cancer. Oncology Life Sci Adv (1993), 12, 23-33.

112) U. Kurzik-Dumke, R. Müllenbach, K. Holzmann, E. Gateff, N. Blin and S. Dooley. Genetic mapping of a new Drosophila fos related sequence isolated via PCR technology using mammalian c-fos specific primers. Dros Inf Service (1993), Juli 1993.

113) I. Wundrack and S. Dooley. Nonradioactive ribonuclease protection analysis using digoxygenine labeling and chemiluminescent detection. Electrophoresis (1992), 13, 637-638.

114) S. Dooley, C. Welter and N. Blin. DNA-protein interaction analysis using polyacrylamide gel electrophoresis and a simple and sensitive UV crosslinking procedure. Electrophoresis (1992), 13, 333-334.

115) R. Müllenbach, S. Lutz, K. Holzmann, S. Dooley and N. Blin. A non-alphoid repetitive DNA sequence from human chromosome 21. Hum Genet (1992), 89, 519-523.

116) S. Dooley, U. Färber, C. Welter, B. Theisinger and N. Blin. Cross-hybridization between the avian myeloblastosis oncogene and eukaryotic 28S ribosomal RNA. Gene (1992), 110, 263-264.

117) S. Dooley, C. Welter and N. Blin. Nonradioactive southwestern analysis using chemiluminescent detection. Biotechniques (1992), 13, 540-543.

118) J. Radtke, S. Dooley, N. Blin and G. Unteregger. A set of 4 nuclear proteins bind to DNA sequence within the fos promoter region. Mol Biol Rep (1991), 15, 87-92.

119) S. Dooley, C. Welter, B. Theisinger and N. Blin. Generating highly labeled oligonucleotides for DNA-protein interaction. Genet Anal Tech Appl (1990), 7, 133-137.

120) S. Dooley, J. Radtke, G. Unteregger and N. Blin. Correlated activation of fos protooncogene transcription and specific binding factors. Cancer J (1990), 3, 10-13.

121) C. Welter, S. Dooley, K.D. Zang and N. Blin. DNA curvature in front of the human mitochondrial L-strand replication origin with specific protein binding. Nucleic Acids Res (1989), 17, 6077-6086.

122) S. Dooley, E. Ehrhart, J. Radtke, G. Unteregger and N. Blin. A procedure for simultaneous isolation of undegraded RNA, DNA and nuclear proteins suitable for interaction analysis in homologous systems. Methods Mol Cell Biol (1989), 1, 95-105.

123) C. Welter, S. Dooley, and N. Blin. A rapid protocol for the purification of mitochondrial DNA suitable for studying restriction fragment length polymorphisms. Gene (1989), 83, 169-172.

124) S. Dooley, J. Radtke, N. Blin and G. Unteregger. Rapid detection of DNA-binding factors with protein-blotting and digoxygenine-dUTP marked probes. Nucleic Acids Res (1988), 16, 11839.